반응 #644449

반응 방정식

4-(pyridin-2-yloxymethyl)-benzaldehyde

sodium methoxide

tetrahydrofuran

methyl chloroacetate

→

title compound

Methyl 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate

용매

ethyl acetate

acetic acid

반응 조건

후처리

1. 1
   workup.STIRRINGwas stirred for two hours at room temperature
2. 2
   기타was allowed to room temperature
3. 3
   추출extracted
4. 4
   기타the organic layer was separated
5. 5
   세척washed with saturated sodium chloride water
6. 6
   건조dried over anhydrous magnesium sulfate
7. 7
   기타The solvent thereof was evaporated under a reduced pressure

실험 절차

To a mixture of 4-(pyridin-2-yloxymethyl)-benzaldehyde described in Preparation Example 1-3-2 (24.8 g) and tetrahydrofuran (160 mL) was added methyl chloroacetate (10.2 mL) at −15° C, and sodium methoxide (23.7 mL, 28% methanol solution) was then added thereto at the same temperature. The reaction mixture was stirred at 0° C for one hour, and then was stirred for two hours at room temperature. The reaction mixture was added to ice water (800 mL) containing acetic acid (6 mL), and the reaction mixture was allowed to room temperature. To the reaction mixture was added ethyl acetate, and extracted, then, the organic layer was separated, washed with saturated sodium chloride water, and dried over anhydrous magnesium sulfate. The solvent thereof was evaporated under a reduced pressure to obtain the title compound (30.2 g).

출처