반응 #64426

반응 방정식

1-bromopentane

3-Bromophenol

potassium carbonate

→

3-bromo-phenol

n-pentyl ether

용매

dimethylformamide

반응 조건

후처리

1. 1
   온도cooled to room temperature
2. 2
   여과filtered
3. 3
   workup.ADDITIONThe filtrate is diluted with ether
4. 4
   세척washed with water and brine
5. 5
   건조After drying over magnesium sulfate
6. 6
   농축concentrating
7. 7
   기타the crude oil obtained
8. 8
   기타is chromatographed over silica gel
9. 9
   세척eluted with 3:2 hexane

실험 절차

To a solution of 5.0 gm of 3-Bromophenol in 60 mls of dimethylformamide is added 6.0 gm of potassium carbonate followed by 4.3 ml of 1-bromopentane. This mixture is heated to 60° C. for 6 hours and then cooled to room temperature and filtered. The filtrate is diluted with ether and washed with water and brine. After drying over magnesium sulfate and concentrating, the crude oil obtained is chromatographed over silica gel, and eluted with 3:2 hexane:ether to yield 3-bromo-phenol, n-pentyl ether as a clear oil.

출처