반응 #64418
ord-23b48d1c4eb04d21a12c78419eafc48f
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도is cooled in an ice bath
- 2기타The solvent is removed under vacuum
- 3기타The residue obtained
- 4기타chromatographed on normal phase silica gel eluting with a 3:2 ratio of hexane
실험 절차
A mixture of 0.80 g of 60% NaH in 28 ml of anhydrous dimethylformamide is cooled in an ice bath. To this is added 3.01 g of the above 3-pentyloxyphenol oil dissolved in 7 ml of anhydrous dimethylformamide. This mixture is then stirred at room temperature for 45 minutes; 1.81 ml of 3-Bromopropanol are added; and the resultant mixture is stirred at 60° C. for 17 hours. The solvent is removed under vacuum, and the residue worked up in same manner as above. The residue obtained is flash chromatographed on normal phase silica gel eluting with a 3:2 ratio of hexane:ether to yield 3-[3-(pentyloxy)phenoxy]propanol as a pale yellow oil.