반응 #643945

반응 방정식

sodium hydroxide

metformin hydrochloride

acetic acid

→

metformin acetate

수율 52.7%

용매

water

반응 조건

후처리

1. 1
   workup.DISSOLUTIONto dissolve thoroughly
2. 2
   여과The resulting crystal was filtered
3. 3
   세척washed with acetone
4. 4
   기타dried at 60° C.

실험 절차

1 Kg (1 equivalent) of metformin hydrochloride and 2 L of water, and then 0.5 L (1.45 equivalents) of acetic acid were added to a reactor, and stirred for 2 hours at 30° C. to dissolve thoroughly. Then 289.8 g (1.2 equivalents) of aqueous solution of sodium hydroxide were added to the reaction solution for 1 hour. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 601 g of metformin acetate (yield: 52.7%).

출처