반응 #643915

반응 방정식

4a

3-[1-(2-Nitro-phenyl)-1H-pyrrol-2-yl]-propenal

aminoguanidine bicarbonate

→

final product 5a

수율 55.0%

[1-(2-Nitrophenyl)-1H-pyrrol-2-yl-allylideneamino]guanidinium actate

수율 55.0%

용매

THF

반응 조건

후처리

1. 1
   온도refluxed for 30 min
2. 2
   기타The solvent was evaporated
3. 3
   workup.ADDITIONthe residue was diluted with acetonitrile
4. 4
   기타the product crystallised
5. 5
   기타Purification
6. 6
   기타by recrystallisation from acetonitrile

실험 절차

2 g (8.3 mmol) 4a and 1.1 eqv. of aminoguanidine bicarbonate was mixed in THF and refluxed for 30 min. The solvent was evaporated and the residue was diluted with acetonitrile and the product crystallised. Purification by recrystallisation from acetonitrile yielded 1.35 g (55%) of the final product 5a (m.p. 192-194° C.).

출처