반응 #64339
ord-cf15b780d0e5404789b80b8d842efd0d
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타equipped with mechanical stirrer
- 2온도The mixture was heated for 24 hours
- 3온도at reflux
- 4온도cooled
- 5여과The mixture was filtered
- 6세척washed with cold methanol (20 ml)
실험 절차
D-Glucurono-6,3-lactone (100.0 g, 0.57 mole), anhydrous methanol (200.0 g, 6.24 moles), and methanesulfonic acid (3 drops) were placed in an oven dried three-necked round bottom flask equipped with mechanical stirrer, thermometer and condenser. The mixture was heated for 24 hours at reflux, cooled and neutralized with 0.1N methanolic KOH. The mixture was filtered and washed with cold methanol (20 ml) yielding 20.9g of methyl β-D-glucofuranosidurono-6, 3-lactone (MβGlucl). By further concentration of the filtrate an additional 28.2 g of MβGlucl was isolated giving a total yield of 49.1 g (45.3%), MP=139, % Purity=99.1.