반응 #643177

반응 방정식

3,5-dibromo-pyridine

potassium carbonate

ethyl boronic acid

→

title compound

3-Bromo-5-ethyl-pyridine

용매

THF

반응 조건

후처리

1. 1
   기타purged with argon
2. 2
   온도heated
3. 3
   온도to reflux overnight
4. 4
   여과is filtered through Celite® (filter agent)
5. 5
   세척washing with DCM
6. 6
   기타the residue is purified by flash chromatography
7. 7
   세척eluting with DCM

실험 절차

3,5-dibromo-pyridine (0.4 g, 1.688 mmol), potassium carbonate (0.7 g, 5.064 mmol), [1,1′-Bis(diphenylphosphino)ferrocene]palladium(II) chloride (0.138 g, 0.169 mmol), silver(I) oxide (0.902 g, 4.22 mmol), ethyl boronic acid (0.150 g, 2.03 mmol) and THF (8 ml) are mixed together, purged with argon and heated to reflux overnight. After cooling to room temperature the reaction mixture is filtered through Celite® (filter agent) washing with DCM. The DCM is reduced in vacuo and the residue is purified by flash chromatography by loading onto a 20 g silica column eluting with DCM to afford the title compound, [MH+ 185.91 and 187.91].

출처