반응 #64317

반응 방정식

1,6-anhydro-3,4-dideoxy-β-D-threo-hex-3-enopyranose

methanol

iodine

ammonia water

→

1,6:3,4-dianhydro-β-D-talopyranose

수율 93.8%

용매

acetic acid

반응 조건

후처리

1. 1
   workup.STIRRINGAfter the reaction mixture was stirred for 5 hours at room temperature under a nitrogen atmosphere
2. 2
   온도cooling
3. 3
   workup.STIRRINGwas stirred for overnight at room temperature
4. 4
   여과was filtered off
5. 5
   기타the solvent was removed from the filtrate under reduced pressure
6. 6
   기타The residue was purified by means of silica gel column chromatography (hexane: ethyl acetate=1: 1)

실험 절차

0.13 g (1.00 mmol) of 1,6-anhydro-3,4-dideoxy-β-D-threo-hex-3-enopyranose represented by the above formula [3] was dissolved in 4.6 ml of acetic acid, and further 0.33 g (2.00 mmol) of silver acetate was added thereto. While vigorously stirring the solution at room temperature, 0.27 g (1.05 mmol) of iodine was gradually added to the solution. After the reaction mixture was stirred for 5 hours at room temperature under a nitrogen atmosphere, 40 ml of 25% ammonia water was gradually added to the solution while ice-cooling to convert it to a basic solution. Further 40 ml of methanol was added to the basic solution, which was stirred for overnight at room temperature. Undissolved material was filtered off, and the solvent was removed from the filtrate under reduced pressure. The residue was purified by means of silica gel column chromatography (hexane: ethyl acetate=1: 1), thereby obtaining 1.09 g (yield: 93.8%) of 1,6:3,4-dianhydro-β-D-talopyranose represented by the following formula [4] . This was recrystallized from a hexane-diethyl ether mixed solvent (hexane:diethyl ether=1:4). ##STR13##

출처