반응 #642798

반응 방정식

sodium hydroxide

4-methoxycarbonylbenzoic N′-(1-(1-(quinolin-2-yl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)-ethyl)-hydrazide

hydrochloric acid

→

desired product

수율 34.0%

4-carboxybenzoic N′-(1-(1-(quinolin-2-yl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)-ethyl)-hydrazide

수율 34.0%

용매

methanol

반응 조건

후처리

1. 1
   여과the precipitated solid was collected by filtration

실험 절차

1.5 mL of a methanol solution of 14.9 mg (0.034 mmol) of the 4-methoxycarbonylbenzoic N′-(1-(1-(quinolin-2-yl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)-ethyl)-hydrazide synthesized in 1) was stirred with 168 μL (0.168 mmol) of 1M aqueous sodium hydroxide at 50° C. for 12 hours. After the stirring, 168 μL (0.168 mmol) of 1M hydrochloric acid was added, and the precipitated solid was collected by filtration to obtain 4.9 mg of the desired product as a dark yellow solid (yield 34%).

출처