반응 #642797

반응 방정식

1-(1-(quinolin-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl)-ethanone

4-methoxycarbonylbenzhydrazide

p-toluenesulfonic acid monohydrate

→

desired product

수율 31.0%

4-methoxycarbonylbenzoic N′-(1-(1-(quinolin-2-yl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)-ethyl)-hydrazide

수율 31.0%

용매

isopropyl alcohol

반응 조건

후처리

1. 1
   온도with heating for 48 hours
2. 2
   온도After cooling
3. 3
   여과the precipitate was collected by filtration
4. 4
   세척washed with methanol and acetonitrile

실험 절차

2.0 mL of an isopropyl alcohol solution of 28.7 mg (0.11 mmol) of 1-(1-(quinolin-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl)-ethanone, 20.8 mg (0.11 mmol) of 4-methoxycarbonylbenzhydrazide and 6.1 mg (0.03 mmol) of p-toluenesulfonic acid monohydrate was refluxed with heating for 48 hours. After cooling, the precipitate was collected by filtration and washed with methanol and acetonitrile to obtain 14.9 mg of the desired product as a purple solid (yield 31%).

출처