반응 #64277

반응 방정식

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride dihydrate

→

1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate

수율 87.0%

용매

methanol

반응 조건

후처리

1. 1
   기타g, 16.0 mmol, prepared in accordance with the teachings of U.S
2. 2
   workup.DISSOLUTIONThe solid initially dissolved
3. 3
   기타a precipitate formed
4. 4
   여과The precipitate was collected by filtration
5. 5
   세척washed with a small quantity of dry methanol

실험 절차

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride dihydrate (7.37. g, 16.0 mmol, prepared in accordance with the teachings of U.S. Pat. No. 4,25 1,532) was placed in an Edenmeyer flask and dissolved in a minimum amount (about 10 mL) of hot dry methanol. The solid initially dissolved, but soon turned cloudy and a precipitate formed. The precipitate was collected by filtration and washed with a small quantity of dry methanol followed by dry acetone to yield 6.35 g (13.9 mmol, 87.0%) of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate.

출처