반응 #64208

반응 방정식

2-(2,6-difluorophenyl)-4-methanesulfonyloxymethyl-2-oxazoline

4-(4-chlorophenyl)phenol

sodium hydroxide

ammonium chloride

→

2-(2,6-difluorophenyl)-4-{[4-(4-chlorophenyl) phenoxy]methyl}-2-oxazoline

수율 18.2%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   추출extracted twice with ethyl acetate
2. 2
   건조The residue was dried over magnesium sulfate
3. 3
   농축concentrated under reduced pressure

실험 절차

A mixture of 200 mg (0.687 mmol.) of 2-(2,6-difluorophenyl)-4-methanesulfonyloxymethyl-2-oxazoline, 232 mg (1.00 mmol.) of 4-(4-chlorophenyl)phenol, 24 mg (1.0 mmol.) of sodium hydroxide and 3 ml of N,N-dimethylformamide was stirred at room temperature for 24 hours. After the reaction was completed, the reaction mixture was poured into 50 ml of a 10% aqueous solution of ammonium chloride and extracted twice with ethyl acetate. The residue was dried over magnesium sulfate and concentrated under reduced pressure. The residue was subjected to silica gel chromatography to give 50 mg of 2-(2,6-difluorophenyl)-4-{[4-(4-chlorophenyl) phenoxy]methyl}-2-oxazoline as a white solid (m.g. 99.5° C.).

출처