반응 #6414

반응 방정식

p-hydroxybenzoic acid

(-)-2-methylbutanol

sulfuric acid

→

ester

수율 83.0%

2-methylbutyl 4-hydroxybenzoate

수율 83.0%

용매

toluene

반응 조건

후처리

1. 1
   기타while removing the generated water out from the reaction system
2. 2
   세척Subsequently, the reaction solution was washed with water
3. 3
   기타to remove sulfuric acid out
4. 4
   기타The reaction solution was then dried
5. 5
   농축concentrated
6. 6
   기타the concentrate was purified by column chromatography

실험 절차

4.0 g of p-hydroxybenzoic acid and 12.5 g of (-)-2-methylbutanol were refluxed for 6 hours in toluene in the presence of sulfuric acid, while removing the generated water out from the reaction system. Subsequently, the reaction solution was washed with water to remove sulfuric acid out. The reaction solution was then dried and concentrated, and the concentrate was purified by column chromatography, to obtain 5.0 g of the objective ester compound (liquid state at room temperature, [α]D23 =4.9° (CHCl3)). (Yield: 83%)

출처