반응 #6413

반응 방정식

p-hydroxybenzoic acid

(S)-(+)-3-methyl-1-pentanol

sulfuric acid

→

ester

수율 80.7%

3-methylpentyl p-hydroxybenzoate

수율 80.7%

용매

toluene

반응 조건

후처리

1. 1
   기타while removing out the generated water from the reaction system
2. 2
   세척Subsequently, the reaction solution was washed with water
3. 3
   기타to remove the sulfuric acid out
4. 4
   기타The reaction solution was then dried
5. 5
   농축concentrated
6. 6
   기타purified by column chromatography

실험 절차

13.7 g of p-hydroxybenzoic acid and 11.4 g of (S)-(+)-3-methyl-1-pentanol were refluxed for 10 hours in toluene in the presence of sulfuric acid, while removing out the generated water from the reaction system. Subsequently, the reaction solution was washed with water to remove the sulfuric acid out. The reaction solution was then dried, concentrated, and purified by column chromatography, to obtain 17.8 g of the objective ester compound (liquid state at room temperature ([α]D23 =+7.8° (CHCl3)). (Yield: 80%)

출처