반응 #64122

반응 방정식

sodium hydride

4-chloro-8-fluoroquinazoline

2-(4-methylphenyl)ethanol

→

8-fluoro-4-[2-(4-methylphenyl)ethoxy]quinazoline

용매

DMF

반응 조건

후처리

1. 1
   여과The solid was collected by filtration

실험 절차

To a mixture of 0.6 g of sodium hydride (50%, suspension in oil) and 2 g of 4-chloro-8-fluoroquinazoline in 20 ml of DMF was added 1.64 g of 2-(4-methylphenyl)ethanol, and the mixture was stirred for one hour. Then the mixture was poured into ice water. The solid was collected by filtration. Yield: 0.7 g (20.5%). M.P. 72°-74° C.

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