반응 #64119

반응 방정식

NH4OH water

2,4-dichloroquinazoline

2-(2-thienyl)ethylamine

→

title product

수율 50.0%

N,N'-bis[2-(2-thienyl)ethyl]-2,4-quinazolinediamine

수율 50.0%

용매

반응 조건

후처리

1. 1
   온도cooled
2. 2
   workup.ADDITIONwas added
3. 3
   추출The product was extracted into CH2Cl2
4. 4
   농축this solution was concentrated to dryness
5. 5
   기타The residue was purified by HPLC (silica gel, 80% pentane/20% EtOAc)

실험 절차

A mixture of 1.4 g of 2,4-dichloroquinazoline and 3.5 g of 2-(2-thienyl)ethylamine was stirred under nitrogen at 160°-165° C. for one hour, then cooled. To the mixture 200 ml of a 50/50 mixture of NH4OH/water was added. The product was extracted into CH2Cl2, and this solution was concentrated to dryness. The residue was purified by HPLC (silica gel, 80% pentane/20% EtOAc) to provide 1.3 g of the title product Yield: 50.0% M.P. oil.

출처