반응 #6410

반응 방정식

p-hydroxybenzoic acid

(S)-(-)-2-methylbutanol

sulfuric acid

water

→

ester

수율 83.0%

2-methylbutyl p-hydroxybenzoate

수율 83.0%

용매

toluene

반응 조건

후처리

1. 1
   기타was removed out
2. 2
   세척Subsequently, the reaction solution was washed with water
3. 3
   기타to remove sulfuric acid out
4. 4
   기타After the resulting solution was dried
5. 5
   농축concentrated
6. 6
   기타the concentrate was purified by column chromatography

실험 절차

4.0 g of p-hydroxybenzoic acid and 12.5 g of (S)-(-)-2-methylbutanol were refluxed for 6 hours in toluene in the presence of sulfuric acid, while the generated water was removed out. Subsequently, the reaction solution was washed with water to remove sulfuric acid out. After the resulting solution was dried and concentrated, the concentrate was purified by column chromatography to obtain 5.0 g of the objective ester compound (liquid state at room temperature, [α]D23 =+4.9° (CHCl3)). (Yield: 83%)

출처