반응 #64084

반응 방정식

(2S, 5S,6S)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one

sulfuric acid

2-propanol

→

isopropyl (2R, 3S)-2-methyl-3-hydroxybutanoate

용매

water

반응 조건

후처리

1. 1
   추출ether extraction
2. 2
   건조The ether phase was dried over anhydrous sodium sulfate and ether
3. 3
   workup.DISTILLATIONwas distilled off
4. 4
   workup.DISTILLATIONby distilling the residue

실험 절차

To 1.0 g of (2S, 5S,6S)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one produced by a procedure similar to Example 1-(7) were added 0.1 ml of concentrated sulfuric acid and 10 ml of 2-propanol, stirred at room temperature for one hour, and 20 ml of water was added to effect ether extraction. The ether phase was dried over anhydrous sodium sulfate and ether was distilled off followed by distilling the residue to obtain 0.4 g of isopropyl (2R, 3S)-2-methyl-3-hydroxybutanoate of the following formula. ##STR61## (2) Repeating the procedure of Example 5-(1) except that 2-propanol was replaced with 2-butanol, 0.5 g of 1-methylpropyl (2R, 3S)-2-methyl-3-hydroxybutanoate of the following formula was obtained.

출처