반응 #64082

반응 방정식

(2R, 5S, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one

sulfuric acid

2-propanol

→

isopropyl (2S, 3R)-2-methyl-3-hydroxybutanoate

용매

water

반응 조건

후처리

1. 1
   추출followed by ether extraction
2. 2
   건조The ether phase was dried over anhydrous sodium sulfate and ether
3. 3
   workup.DISTILLATIONwas distilled off
4. 4
   workup.DISTILLATIONthe residue was subjected to distillation

실험 절차

To 1.0 g of (2R, 5S, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one obtained by procedure similar to Example 1-(4) were added 0.1 ml of concentrated sulfuric acid and 10 ml of 2-propanol, stirred at room temperature for one hour, and 20 ml of water was added followed by ether extraction. The ether phase was dried over anhydrous sodium sulfate and ether was distilled off, and then the residue was subjected to distillation to obtain 0.4 g of isopropyl (2S, 3R)-2-methyl-3-hydroxybutanoate. ##STR41##

출처