반응 #64081

반응 방정식

(2R, 5R, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one

sulfuric acid

2-propanol

→

isopropyl (2R, 3R)-2-methyl-3-hydroxybutanoate

용매

water

반응 조건

후처리

1. 1
   추출ether extraction
2. 2
   건조After drying the ether phase over anhydrous sodium sulfate
3. 3
   workup.DISTILLATIONthe ether was distilled off
4. 4
   workup.DISTILLATIONthe residue was subjected to distillation

실험 절차

To 1.0 g of (2R, 5R, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one obtained by procedures similar to (1)-(4) of Example 1 were added 0.1 ml of concentrated sulfuric acid and 10 ml of 2-propanol and stirred at room temperature for one hour, and 20 ml of water was added to effect ether extraction. After drying the ether phase over anhydrous sodium sulfate, the ether was distilled off and the residue was subjected to distillation to give 0.4 g of isopropyl (2R, 3R)-2-methyl-3-hydroxybutanoate. The NMR chart is shown in FIG. 6. ##STR31##

출처