반응 #64079

반응 방정식

t-butyl 2-methyl-3hydroxybutanoate

vinyl laurate

→

t-butyl (3S)-2-methyl-3-hydroxybutanoate

수율 43.3%

반응 조건

후처리

1. 1
   기타the reaction
2. 2
   기타the enzyme was removed by filtration
3. 3
   세척washed with n-heptane on a filter paper
4. 4
   workup.DISTILLATIONn-Heptane was distilled off from the filtrate
5. 5
   workup.DISTILLATIONthe residue was subjected to a vacuum distillation

실험 절차

A mixture of a racemate, t-butyl 2-methyl-3hydroxybutanoate 30 g, vinyl laurate 40 g, and Lipase P (Amano Pharmaceutical Co., Ltd.) 8.0 g was stirred at 35° C. for 7 days. After stopping the reaction, the enzyme was removed by filtration and washed with n-heptane on a filter paper. n-Heptane was distilled off from the filtrate and the residue was subjected to a vacuum distillation to give 13 g of t-butyl (3S)-2-methyl-3-hydroxybutanoate of the following formula, ##STR25## and 23 g of t-butyl (3R)-2-methyl-3-dodecanoyloxy butanoate of the following formula, ##STR26##

출처