반응 #640634

반응 방정식

3-(2-thienyl)quinoxalin-2(1 H)-one

POCl3

→

2-chloro-3-(2-thienyl)quinoxaline

수율 74.0%

반응 조건

후처리

1. 1
   온도was heated
2. 2
   기타After the material was consumed
3. 3
   기타The solid was collected
4. 4
   기타dried in vacuo

실험 절차

A mixture of 3-(2-thienyl)quinoxalin-2(1 H)-one (500 mg, 2.19 mmol.) and POCl3 (6 mL) was heated to reflux at 120° C. After the material was consumed, the reaction mixture was taken up with water and ice. The solid was collected and dried in vacuo to give 2-chloro-3-(2-thienyl)quinoxaline (400 mg, 74%). 1 H NMR (400 MHz, CDCl3) δ 8.22 (d, J=4.8 Hz, 1 H), 8.00 (d, J=10.4 Hz, 1 H), 7.91 (d, J=10.4 Hz, 1 H), 7.72˜7.61 (m, 2 H), 7.52 (d, J=6.8 Hz, 1 H), 7.13 (t, J=6.0 Hz, 1 H).

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