반응 #640632

반응 방정식

2-chloro-benzoimidazole

K2CO3

isobutyl iodide

→

2-chloro-1-isobutyl-benzoimidazole

수율 96.0%

용매

DMF

반응 조건

후처리

1. 1
   추출The mixture was extracted with ethyl acetate (3×100 mL)
2. 2
   세척washed with brine
3. 3
   건조dried over Na2SO4
4. 4
   농축concentrated
5. 5
   기타to get a residue, which
6. 6
   기타was purified by column chromatography

실험 절차

To a solution of 2-chloro-benzoimidazole (1.0 eq.) in DMF was added K2CO3 (2.0 eq.) and isobutyl iodide (1.5 eq.). The reaction mixture was stirred at room temperature for 3 days. The reaction mixture was poured into ice-water. The mixture was extracted with ethyl acetate (3×100 mL), washed with brine, dried over Na2SO4, concentrated to get a residue, which was purified by column chromatography to afford 4 g (96%) of 2-chloro-1-isobutyl-benzoimidazole.

출처