반응 #640612

반응 방정식

Imatinib

methane sulfonic acid

→

Imatinib mesylate

용매

ethanol

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도under reflux for 20 minutes
3. 3
   여과than filtered at 65° C
4. 4
   기타The filtrate was evaporated down to 50%
5. 5
   여과the residue filtered off at 25° C.
6. 6
   여과(filter material A)
7. 7
   기타The mother liquor was evaporated to dryness
8. 8
   여과The residue and filter material A
9. 9
   workup.DISSOLUTIONdissolved
10. 10
    온도under reflux with addition of water
11. 11
    온도Cooling
12. 12
    여과overnight to 25° C., filtration
13. 13
    기타drying

실험 절차

Imatinib base was suspended in ethanol, methane sulfonic acid was added and heated under reflux for 20 minutes and than filtered at 65° C. The filtrate was evaporated down to 50% and the residue filtered off at 25° C. (filter material A). The mother liquor was evaporated to dryness. The residue and filter material A were suspended in ethanol dissolved under reflux with addition of water. Cooling overnight to 25° C., filtration and drying yielded Imatinib mesylate α-crystal form.

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