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1-[4-[4-(4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carbonyl)-piperazin-1-yl]-phenyl]-ethanone

p-toluenesulfonic acid chloride

→

1-(4-{4-[5-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carbonyl]-piperazin-1-yl}-phenyl)-ethanone

수율 28.1%

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실험 절차

In a manner similar to the general method, 170 mg (0.42 mmol) of 1-[4-[4-(4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carbonyl)-piperazin-1-yl]-phenyl]-ethanone were reacted with 120 mg (0.63 mmol) of p-toluenesulfonic acid chloride to yield 60 mg (28% of theoretical) of 1-(4-{4-[5-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carbonyl]-piperazin-1-yl}-phenyl)-ethanone (86), which were obtained in the form of a colourless solid.

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