반응 #640608

반응 방정식

6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester

4-piperazinoacetophenone

→

3-[4-(4-acetyl-phenyl)-piperazine-1-carbonyl]-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester

수율 42.4%

반응 조건

실험 절차

In a manner similar to general method 1, 1.1 g (4.1 mmol) of 6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester were reacted with 838 mg (4.1 mmol) of 4-piperazinoacetophenone to yield 790 mg (42% of theoretical) of 3-[4-(4-acetyl-phenyl)-piperazine-1-carbonyl]-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester, which were obtained in the form of a yellow-orange oil.

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