반응 #640595
ord-3cbf28d41e1143919c8fbdf7395a26de
반응 방정식
(4(S)-phenyloxazolidin-2-on-3-yl)acetic acid
oxalyl chloride
dimethylformamide
→
title compound
(4(S)-phenyloxazolidin-2-on-3-yl)acetyl chloride
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타resulting in vigorous gas evolution
- 2농축the reaction mixture was concentrated under reduced pressure
실험 절차
A solution of 1.0 equivalent of (4(S)-phenyloxazolidin-2-on-3-yl)acetic acid (Evans, U.S. Pat. No. 4,665,171) and 1.3 equivalent of oxalyl chloride in 200 mL dichloromethane was treated with a catalytic amount of anhydrous dimethylformamide (85 μL/milliequivalent of acetic acid derivative) resulting in vigorous gas evolution. After 45 minutes all gas evolution had ceased and the reaction mixture was concentrated under reduced pressure to provide the title compound as an off-white solid after drying for 2 h under vacuum.