반응 #640590

반응 방정식

cyanogen bromide

Boc2O

N-phenylethylenediamine

3,4-difluorobenzyl bromide

→

title compound

1-(3,4-Difluorobenzyl)-3-phenyl-imidazolidin-2-ylideneamine

반응 조건

후처리

1. 1
   기타the crude product was isolated upon aqueous work-up

실험 절차

The title compound was prepared from N-phenylethylenediamine in four steps by Procedure A. In the first step, one equivalent of Boc2O was used and, similarly, one equivalent of 3,4-difluorobenzyl bromide was used as benzylating reagent in the second step. After reacting with cyanogen bromide, the crude product was isolated upon aqueous work-up and purified by preparative LCMS to give the title compound as the free base. MS (ES+) m/z 288 ([M+1]+, 100); HR-MS: 288.1316 ([M+1]+, C16H16F2N3; calc. 288.131228).

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