반응 #640541

반응 방정식

6-aminonicotinic acid

ethanol

→

white solid

Ethyl 6-Aminonicotinate

반응 조건

후처리

1. 1
   기타was bubbled in dry hydrochloric acid at 0° C.
2. 2
   온도the solution was refluxed until all the solids
3. 3
   workup.DISSOLUTIONdissolved
4. 4
   기타The solvents were removed under reduced pressure
5. 5
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
6. 6
   세척washed with saturated sodium bicarbonate, brine
7. 7
   농축concentrated

실험 절차

To a suspension of 1.3 g (9.4 mmol) 6-aminonicotinic acid in 100 mL of ethanol, was bubbled in dry hydrochloric acid at 0° C., then the solution was refluxed until all the solids dissolved. The solvents were removed under reduced pressure, the residue dissolved in ethyl acetate, washed with saturated sodium bicarbonate, brine and concentrated to afford 1.37 g of a white solid, m/e=166(M+H).

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