반응 #640533

반응 방정식

4-[1-(3-methoxy-4-hydroxyphenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

DIPEA

methoxymethyl chloride

→

title compound

4-[1-(3-Methoxy-4-methoxymethoxy-phenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

용매

DMF

ethyl acetate

반응 조건

후처리

1. 1
   세척washed with water
2. 2
   건조dried over sodium sulphate
3. 3
   여과Filtration of the sodium sulphate and concentration of the filtrate under reduced pressure

실험 절차

A mixture of 4-[1-(3-methoxy-4-hydroxyphenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.10 g, 0.27 mmol), DIPEA and methoxymethyl chloride in dry DMF is stirred at room temperature for 14 hours. The reaction mixture is diluted with ethyl acetate, washed with water and dried over sodium sulphate. Filtration of the sodium sulphate and concentration of the filtrate under reduced pressure gives the title compound as colorless, pure solid, m.p. 190° C.

출처