반응 #640523

반응 방정식

diiodomethane

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

4-fluorophenol

→

title compound

4-[1-(4-Fluorophenoxymethyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

반응 조건

후처리

1. 1
   기타Evaporation of the solvent under reduced pressure
2. 2
   기타partitioning of the resulting residue between water and ethyl acetate
3. 3
   건조by drying of the organic solution over sodium sulphate and chromatography of the residue

실험 절차

To a solution of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.10 g, 0.497 mmol) is added potassium carbonate (0.172 g, 1.24 mmol) followed by 4-fluorophenol (0.0557 g, 0.497 mmol) and diiodomethane (0.133 g, 0.497 mmol). The mixture is stirred over night. Evaporation of the solvent under reduced pressure and partitioning of the resulting residue between water and ethyl acetate followed by drying of the organic solution over sodium sulphate and chromatography of the residue gives the title compound as a colorless solid, m.p. 155-158° C.

출처