반응 #640521

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4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

methanol

acrylonitrile

→

title compound

4-(1H-Benzimidazol-2-yl)-furazan-3-yl-N-(2-cyanoethyl)-amine

용매

pyridine

반응 조건

후처리

1. 1
   기타Evaporation of the solvent under reduced pressure
2. 2
   기타partitioning of the resulting residue between water and ethyl acetate
3. 3
   건조by drying of the organic solution over sodium sulphate

실험 절차

To a solution of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.10 g, 0.497 mmol) in pyridine (5 ml) sodium in methanol (0.02 g, 0.86 mmol in 1 ml) and acrylonitrile (0.03 g, 0.39 mmol) are added sequentially at 0° C. The mixture is stirred over night. Evaporation of the solvent under reduced pressure and partitioning of the resulting residue between water and ethyl acetate followed by drying of the organic solution over sodium sulphate gives the title compound in pure form. 1H-NMR (400 MHz, d6-DMSO): 13.7 (s, 1H); 7.82 (d, 1H); 7.60 (d, 1H); 7.36 (m, 2H); 7.20 (t, 1H); 3.67 (q, 2H); 2.94 (t, 2H).

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