반응 #640518

반응 방정식

4-[1-(4-chlorophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

potassium carbonate

dimethylsulfate

→

title compound

Methyl-{4-[1-(4-chlorophenacyl)-1H-benzimidazol-2-yl]-furazan-3-yl}-amine

용매

acetone

반응 조건

후처리

1. 1
   여과Filtration of the solids, concentration of the filtrate under reduced pressure and chromatography of the residue on silicagel

실험 절차

A suspension of 4-[1-(4-chlorophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.10 g, 0.282 mmol, prepared according to Example 1), potassium carbonate (0.233 g, 1.69 mmol) and dimethylsulfate (0.142 g, 1.12 mmol) in acetone (5 ml) is stirred at room temperature for 16 hours. Filtration of the solids, concentration of the filtrate under reduced pressure and chromatography of the residue on silicagel using hexane-ethyl acetate as eluent gives the title compound as a colorless solid, m.p. 210-214° C.

출처