반응 #640516

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Phenacylbromid

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

→

title compound

4-(1-Phenacyl-1H-benzimidazol-2-yl)-furazan-3-ylamine

용매

DMF

ethyl acetate

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후처리

1. 1
   기타at room temperature
2. 2
   세척the organic phase is washed repeatedly with brine
3. 3
   기타Drying of the solvent
4. 4
   여과filtering
5. 5
   기타evaporation of the solvent under reduced pressure

실험 절차

Phenacylbromid (0.1 g, 0.49 mmol) is added to an efficiently stirred suspension of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.1 g, 0.4 mmol) [A. V. Sergievskii, O. A. Krasnoshek, S. F. Mel'nikova, I. V. Tselinskii, Russian Journal of Organic Chemistry, 2002, 38, 915-917] and potassium carbonate (0.172 g, 1.24 mmol) in dry DMF (5 ml) at room temperature. After 4 hours the reaction mixture is diluted with ethyl acetate and the organic phase is washed repeatedly with brine. Drying of the solvent, filtering and evaporation of the solvent under reduced pressure gives the title compound in crude form. The title compound is obtained in pure form by chromatography over silicagel, m.p. 202-204° C.

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