반응 #64018

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1-(4-methoxyphenyl)-N-methyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide

1-decene

1-octadecene

→

3-(4-Methoxyphenyl)-3-(1H-1,2,4-triazol-1-ylmethyl)-2-methyl-5-n-octylisoxazolidine

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후처리

1. 1
   기타Derivative 3 (R=4-OCH3, n=7) is prepared by a procedure similar to
2. 2
   workup.ADDITIONThe resulting diastereomeric mixture of cis- and trans-derivative 3 (R=4-OCH3, n=7)
3. 3
   기타is flash-chromatographed on neutral silica gel

실험 절차

Derivative 3 (R=4-OCH3, n=7) is prepared by a procedure similar to that described in Example 1 by reacting 1-(4-methoxyphenyl)-N-methyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide (1: R=4-OCH3) with 1-decene (2: n=7). The resulting diastereomeric mixture of cis- and trans-derivative 3 (R=4-OCH3, n=7) is flash-chromatographed on neutral silica gel using chloroform-methanol (99:1 by volume) as eluent. Isomer A has a melting point of 89°-91° C. (ethyl acetate).

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