반응 #64017

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1-phenyl-N-methyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide

1-(4-chlorophenyl)-N-methyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide

1-octene

1-octadecene

→

3-Phenyl-3-(1H-1,2,4-triazol-1-ylmethyl)-2-methyl-5-n-hexylisoxazolidine

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후처리

1. 1
   기타Derivative 3 (R=H, n=5) is prepared by a procedure similar to
2. 2
   기타is flash-chromatographed on neutral silica gel using as eluent a 98:2
3. 3
   workup.ADDITIONby volume mixture of chloroform-methanol

실험 절차

Derivative 3 (R=H, n=5) is prepared by a procedure similar to that described in Example 1 by reacting 1-phenyl-N-methyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide (1: R=H) with 1-octene (2: n=5). The resulting cis- and trans-diastereomeric mixture of compound 3 (R=H, n=5) is flash-chromatographed on neutral silica gel using as eluent a 98:2 by volume mixture of chloroform-methanol. Isomer A has a melting point of 93°-99° C. (ethyl acetate).

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