반응 #63995

반응 방정식

hydrochloric acid

potassium acid phosphate

dimethyl 3-methylglutarate

potassium carbonate

→

desired product

3-(R)-methylglutaric acid mono methyl ester

용매

CH3OH

반응 조건

후처리

1. 1
   기타four necked flask fitted with
2. 2
   workup.ADDITIONwas added 2.5 1
3. 3
   추출the product extracted with diethyl ether
4. 4
   건조dried over magnesium sulfate
5. 5
   농축concentrated in vacuo
6. 6
   기타to give 114 g

실험 절차

To a 5 1. four necked flask fitted with a stirred and pH electrode was added 2.5 1. of 0.1M potassium acid phosphate buffer pH 7.0 followed by 150 mg. of pig liver esterase and 150 g. of dimethyl 3-methylglutarate. The pH of the mixture was maintained at about 6.85 by periodic addition of a 10% potassium carbonate solution. After 2.5 hours the reaction was acidified with 10% hydrochloric acid to pH 2.0 and the product extracted with diethyl ether. The extracts were combined, dried over magnesium sulfate and concentrated in vacuo to give 114 g. of the desired product, [alpha]D =-1.48 (CH3OH C=0.086 g/ml).

출처