반응 #63979

반응 방정식

hydrochloric acid

1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile

propyl magnesium bromide

ether

propyl bromide

magnesium

ether

ether

→

1-butyryl-1-(3,4-dichlorophenyl)cyclobutane

용매

toluene

Water

반응 조건

후처리

1. 1
   온도the mixture heated
2. 2
   온도under reflux for one hour
3. 3
   온도the mixture heated
4. 4
   온도under reflux for one hour
5. 5
   추출The reaction mixture was extracted with ether
6. 6
   세척after washing
7. 7
   기타drying the extract

실험 절차

A solution of 1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile prepared as described in Example 1 (35.2 g) in ether (100 ml) was added to a solution of propyl magnesium bromide prepared by the reaction of propyl bromide (32 g) with magnesium turnings (6.36 g) in ether (100 ml). The ether was replaced by dry toluene and the mixture heated under reflux for one hour. Water (200 ml) and then concentrated hydrochloric acid (120 ml) were added and the mixture heated under reflux for one hour. The reaction mixture was extracted with ether and after washing and drying the extract yielded a residue from which 1-butyryl-1-(3,4-dichlorophenyl)cyclobutane (b.p. 120°-128° C. at 0.25 mm) was distilled.

출처