반응 #63871

반응 방정식

N-(3-Hydroxybenzyl)piperidine

6-bromohexanenitrile

potassium carbonate

→

6-(3-piperidinomethylphenoxy)hexanenitrile

용매

acetone

반응 조건

후처리

1. 1
   온도The reaction mixture was cooled
2. 2
   여과filtered
3. 3
   기타The solvent was removed by evaporation
4. 4
   온도the residue was heated
5. 5
   기타to remove unreacted 6-bromohexanenitrile

실험 절차

N-(3-Hydroxybenzyl)piperidine (9.55 g) was heated with 6-bromohexanenitrile (10.2 g) and potassium carbonate (13.8 g) under reflux in acetone (150 ml) for 66 hours. The reaction mixture was cooled and filtered. The solvent was removed by evaporation and the residue was heated with stirring at 100° C. for one hour to remove unreacted 6-bromohexanenitrile and to yield 6-(3-piperidinomethylphenoxy)hexanenitrile as an oil.

출처