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4′,5′-difluoro-2′-methoxy-biphenyl-4-ol

6-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indole-1-carboxylic acid tert-butyl ester

4-hydroxymethyl-indole-1-carboxylic acid tert-butyl ester

→

4-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indole-1-carboxylic acid tert-butyl ester

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실험 절차

4-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indole-1-carboxylic acid tert-butyl ester was synthesized by a procedure similar to 6-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indole-1-carboxylic acid tert-butyl ester from starting materials 4-hydroxymethyl-indole-1-carboxylic acid tert-butyl ester and 4′,5′-difluoro-2′-methoxy-biphenyl-4-ol to yield the product as a white solid (880 mg, 70%). LC-MS (ES) calculated for C27H25F2NO2, 465.2; found m/z 466 [M+H]+.

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