반응 #63859

반응 방정식

acetic acid

(E)-4-ethyl-2-hydroxyimino-5-nitro-3-hexenamide

diazomethane

→

(E)-4-ethyl-2-methoxyimino-5-nitro-3-hexenamide

용매

methanol

반응 조건

후처리

1. 1
   workup.WAITto stand at 0° C. for an hour
2. 2
   기타The resulting reaction mixture
3. 3
   기타was evaporated under reduced pressure
4. 4
   기타to give an oil which
5. 5
   기타was purified by preparative thin layer chromatography

실험 절차

To (E)-4-ethyl-2-hydroxyimino-5-nitro-3-hexenamide (37 mg) in methanol (5 ml) was added excess etheral diazomethane at -20° C. The resulting mixture was allowed to stand at 0° C. for an hour and then acetic acid was added thereto until the yellow color of the solution was discharged. The resulting reaction mixture was evaporated under reduced pressure to give an oil which was purified by preparative thin layer chromatography, developing with chloroform containing 5% methanol to give (E)-4-ethyl-2-methoxyimino-5-nitro-3-hexenamide (21.5 mg).

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