반응 #63827

반응 방정식

2-[3-chloro-4-[(2,4-dichlorophenyl)hydroxymethyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione

thionyl chloride

→

2-[3-chloro-4-[chloro(2,4-dichlorophenyl)methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione

용매

trichloromethane

반응 조건

후처리

1. 1
   workup.ADDITIONare added dropwise, during a period of 5 minutes
2. 2
   온도at reflux temperature
3. 3
   기타The reaction mixture is evaporated in vacuo
4. 4
   workup.ADDITIONMethylbenzene is added
5. 5
   기타the whole is evaporated again

실험 절차

To a stirred mixture of 16 parts of 2-[3-chloro-4-[(2,4-dichlorophenyl)hydroxymethyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione and 150 parts of trichloromethane are added dropwise, during a period of 5 minutes, 16 parts of thionyl chloride. Upon completion, stirring is continued for 3 hours at reflux temperature. The reaction mixture is evaporated in vacuo. Methylbenzene is added and the whole is evaporated again, yielding 2-[3-chloro-4-[chloro(2,4-dichlorophenyl)methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione.

출처