반응 #63823

반응 방정식

methyl 3-hydroxypyridine-2-carboxylate

KOH

N,N-dimethylaminothiocarbamoyl chloride

→

white solid

수율 75.8%

Methyl 3-(N,N-dimethylaminothiocarbamoyloxy)pyridine-2-carboxylate

수율 75.8%

용매

water

반응 조건

후처리

1. 1
   기타The solution was partitioned between benzene and water
2. 2
   세척the aqueous layer was washed with two portions of water
3. 3
   기타The combined extracts were dried
4. 4
   농축concentrated

실험 절차

A solution of 3.06 g (20 mmol) of methyl 3-hydroxypyridine-2-carboxylate in 15 mL of water was made basic with 1.12 g KOH. To this solution was added 3.2 g (26 mmol) of N,N-dimethylaminothiocarbamoyl chloride and the solution was stirred at room temperature for 2 hours. The solution was partitioned between benzene and water and the aqueous layer was washed with two portions of water. The combined extracts were dried and concentrated to afford 4.1 g of a white solid, m.p. 74°-75° C.

출처