반응 #63780

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N-propargyl-2,4-dimethyl-5-(trifluoromethanesulfonamido)benzenesulfonamide

triethylamine

acetyl chloride

tetrahydrofuran

→

N-acetyl-N-propargyl-2,4-dimethyl-5-(N-acetyl-N-trifluormethanesulfonylamino)benzenesulfonamide

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated
2. 2
   추출extracted with chloroform
3. 3
   농축The extract was concentrated
4. 4
   기타to give an oily substance, which
5. 5
   기타was purified by silica gel chromatography

실험 절차

To a solution of N-propargyl-2,4-dimethyl-5-(trifluoromethanesulfonamido)benzenesulfonamide (1.5 g) and triethylamine (1.2 g) in tetrahydrofuran (20 ml), acetyl chloride (1.0 g) was added, and the resultant mixture was allowed to stand at room temperature overnight. The reaction mixture was concentrated, admixed with 5% hydrochloric acid and extracted with chloroform. The extract was concentrated to give an oily substance, which was purified by silica gel chromatography to give 1.4 g of N-acetyl-N-propargyl-2,4-dimethyl-5-(N-acetyl-N-trifluormethanesulfonylamino)benzenesulfonamide (Compound No. 75). nD20 1.5209.

출처