반응 #63654

반응 방정식

methoxyacetic acid

methoxyacetyl chloride

carnitine chloride

→

methoxy acetyl carnitine chloride

수율 75.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   기타was brought to 40° C.
3. 3
   workup.STIRRINGunder stirring for seven days
4. 4
   여과the unreacted carnitine chloride was filtered off
5. 5
   workup.ADDITIONUpon addition of tert-butyl methyl ether an oil
6. 6
   기타precipitated
7. 7
   기타The oil precipitation
8. 8
   기타The oil which finally separated

실험 절차

A mixture of methoxyacetic acid (3 ml; 0.04 moles) and methoxyacetyl chloride (3 ml; 0.03 moles) was kept under stirring at 30° C. for 2 hours. To this mixture carnitine chloride (4 g; 0.02 moles) which had been previously dried was added. The resulting mixture was brought to 40° C. and kept under stirring for seven days. The mixture was then taken up with acetonitrile and the unreacted carnitine chloride was filtered off. Upon addition of tert-butyl methyl ether an oil precipitated. The oil precipitation was repeated four times with acetonitrile/tert butyl methyl ether. The oil which finally separated was lyophilized. Four grams of methoxy acetyl carnitine chloride were thus obtained. Yield: 75%

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