반응 #636271

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quinoline-3,4-diamine

[1,5]naphthyridine-3,4-diamine

→

1H-imidazo[4,5-c][1,5]naphthyridine

1H-imidazo[4,5-c]quinoline

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후처리

1. 1
   기타In step (4) of Reaction Scheme I

실험 절차

In step (4) of Reaction Scheme I, a quinoline-3,4-diamine or [1,5]naphthyridine-3,4-diamine of Formula XIX is reacted with a carboxylic acid equivalent, which is selected such that it will provide the desired —X-Hal substituent in a 1H-imidazo[4,5-c]quinoline or 1H-imidazo[4,5-c][1,5]naphthyridine of Formula XX. Suitable carboxylic acid equivalents include ortho esters, acid halides, imidates, and imidate salts.

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