반응 #63611

반응 방정식

2-chloro-N-(5-fluoro-2-methylphenyl)acetamide

hexahydro-3,3-dimethyl-3H-oxazolo[3,4-a]pyrazine

N,N-diethylethanamine

→

N-(5-fluoro-2-methylphenyl)-tetrahydro-3,3-dimethyl-3H-oxazolo[3,4-a]pyrazine-7(8H)-acetamide

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   온도After cooling overnight to room temperature
2. 2
   기타the reaction mixture was evaporated
3. 3
   workup.DISSOLUTIONThe residue was dissolved in trichloromethane
4. 4
   세척The solution was washed with water
5. 5
   기타dried
6. 6
   여과filtered
7. 7
   기타evaporated

실험 절차

A mixture of 6.6 parts of 2-chloro-N-(5-fluoro-2-methylphenyl)acetamide, 5 parts of hexahydro-3,3-dimethyl-3H-oxazolo[3,4-a]pyrazine, 6.1 parts of N,N-diethylethanamine and 67.5 parts of N,N-dimethylformamide was stirred and heated for 8 hours at about 70° C. After cooling overnight to room temperature, the reaction mixture was evaporated. The residue was dissolved in trichloromethane. The solution was washed with water, dried, filtered and evaporated, yielding 8.5 parts of N-(5-fluoro-2-methylphenyl)-tetrahydro-3,3-dimethyl-3H-oxazolo[3,4-a]pyrazine-7(8H)-acetamide as an oily residue (intermediate 121).

출처