반응 #63595

반응 방정식

hydrogen

thiophene

benzaldehyde

2-piperazinecarboxamide

→

4-(phenylmethyl)-2-piperazinecarboxamide

수율 55.0%

용매

methanol

ethanol

반응 조건

후처리

1. 1
   여과the catalyst was filtered off
2. 2
   기타the filtrate was evaporated
3. 3
   여과The mixture was filtered
4. 4
   기타to crystallize at room temperature
5. 5
   여과The product was filtered off
6. 6
   기타dried

실험 절차

To 1 part of a solution of 2 parts of thiophene in 40 parts of ethanol were added 2.2 parts of benzaldehyde, 2.6 parts of 2-piperazinecarboxamide and 120 parts of methanol. The whole was hydrogenated at normal pressure and at room temperature with 2 parts of platinum-on-charcoal catalyst 5%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The solid residue was boiled in 64 parts of acetonitrile. The mixture was filtered and the filtrate was allowed to crystallize at room temperature. The product was filtered off and dried, yielding 2.4 parts (55%) of 4-(phenylmethyl)-2-piperazinecarboxamide; mp. 168.3° C. (intermediate 36).

출처