반응 #635159

반응 방정식

phosphorus oxychloride

3-(4-fluorophenyl)-1-isopropyl-1H-indole

methyl trans-3-methoxyacrylate

water

→

methyl trans-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]acrylate

수율 65.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   기타a reaction
2. 2
   기타After completion of the reaction

실험 절차

2.53 g of 3-(4-fluorophenyl)-1-isopropyl-1H-indole, 2.32 g of methyl trans-3-methoxyacrylate, 0.3 g of water and 15 mL of acetonitrile were mixed, then, 2.51 g of phosphorus oxychloride was added dropwise into the mixture at an inner temperature of 25° C., the added mixture was stirred for 19 hours at the same temperature to cause a reaction. After completion of the reaction, the same post treatment was conducted as in Example 1 to obtain 2.17 g of methyl trans-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]acrylate (yellow solid). Yield: 65%.

출처