반응 #6348

반응 방정식

9-benzyloxy-6-phthalimidopurine

ethanol

→

title compound

수율 83.5%

9-Hydroxy-6-phthalimidopurine

수율 83.5%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   여과The suspension was then filtered
2. 2
   세척the catalyst washed with ethanol
3. 3
   기타The filtrate was evaporated under reduced pressure
4. 4
   기타the resulting solid triturated with ether
5. 5
   기타The solid was collected
6. 6
   기타dried

실험 절차

A mixture of 9-benzyloxy-6-phthalimidopurine (11.0 g, 29.5 mmol), 10% palladium on charcoal (2.2 g), ethanol (300 ml) and tetrahydrofuran (500 ml) was stirred at 25° C. for 1 hour under an atmosphere of hydrogen. The suspension was then filtered and the catalyst washed with ethanol. The filtrate was evaporated under reduced pressure and the resulting solid triturated with ether. The solid was collected and then dried to afford the title compound (6.93 g; 83%). IR: νmax (KBr). 2607, 1794, 1735, 1603, 1582, 1467, 1401 cm-1 ; 1H NMR δH [(CD3)2SO] 8.15(4H, s, Ar), 8.95(1H, s, H-2), 9.15(1H, s, H-8), 12.80(1H, br.s, D2O exchangeable, OH). Found: C, 55.34; H, 2.58; N, 24.56%. C13H7N5O3 requires: C, 55.51; H, 2.51; N, 24.91%.

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